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HIGHLIGHTS OF PRESCRIBING INFORMATION These …

HIGHLIGHTS OF PRESCRIBING INFORMATION Subcutaneous Administration for Adult PsA ( ). These HIGHLIGHTS do not include all the INFORMATION needed to use ORENCIA safely Administer by subcutaneous injection once weekly without the need of an and effectively. See full PRESCRIBING INFORMATION for ORENCIA. intravenous loading dose. ORENCIA (abatacept) for injection, for intravenous use Patients transitioning from ORENCIA (abatacept) intravenous therapy to ORENCIA (abatacept) injection, for subcutaneous use subcutaneous administration should administer the first subcutaneous dose instead Initial Approval: 2005 of the next scheduled intravenous dose. ----------------------------- RECENT MAJOR CHANGES------------------------------ General Dosing INFORMATION for Intravenous Administration ( and ). Indications and Usage, Juvenile Idiopathic Arthritis ( ) 3/2017 Administer as a 30-minute intravenous infusion ( , ). Indications and Usage, Adult Psoriatic Arthritis (PsA) ( ) 6/2017 Following initial dose, give at 2 and 4 weeks, then every 4 weeks ( ).

FULL PRESCRIBING INFORMATION 1 INDICATIONS AND USAGE 1.1 Adult Rheumatoid Arthritis (RA) ORENCIA® (abatacept) is indicated for reducing signs and symptoms, inducing major clinical response, inhibiting the progression of structural damage, and improving physical function in adult patients with moderately to severely active rheumatoid arthritis.

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