Transcription of LACTOSE MONOHYDRATE - uspbpep.com
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LACTOSE MONOHYDRATE - uspbpep.com
EUROPEAN PHARMACOPOEIA monohydrateBulkandtappeddensity( ). Determine the bulkdensity and the tapped density. Calculate the Hausner indexusing the following expression:V0=volume of bulk substance,Vf=volume of tapped substance. - LACTOSE and ( ).Silylation Rand 72 volumes ofpyridine solution. Dissolve about 1 mg of the substance to beexamined in ml ofdimethyl sulphoxide the silylation reagent. Mix gently and allow to stand for20 solution. Prepare a mixture of -lactosemonohydrate Rand - LACTOSE Rhaving an anomeric ratio ofabout 1:1 based on the labelled anomeric contents of the - LACTOSE MONOHYDRATE and - LACTOSE . Dissolve about 1 mgof this mixture in ml ofdimethyl sulphoxide ml of the silylation reagent.
EUROPEAN PHARMACOPOEIA 5.0 Lactose monohydrate Bulkandtappeddensity(2.9.15).Determine the bulk density and the tapped density. Calculate the Hausner index using the following expression:
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