Coupling Reagents - Bachem
Coupling Reagents 2. COUPLING REAGENTS AND . ... amino acid. PG, PG’: protecting groups. Act: activating group. Coupling Reagents 4 tendency to racemize considerably. Ure-thane derivatives, which include standard α-amino protecting groups as Fmoc, Boc, and Z, of amino acids usually retain their optical purity upon …
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ORTHOGONALITY OF PROTECTING GROUPS - …
documents.bachem.comORTHOGONALITY OF PROTECTING GROUPS ... the amino-protecting group intact. On the other hand, the pairs Boc/OPp or Fmoc/ ivDde are merely quasi-orthogonal because both groups are acid-labile or cleaved by bases, respectively. OPp can be removed selectively in the presence of Boc/tBu by
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