4.1.2. STANDARD SOLUTIONS FOR LIMIT TESTS - …

1 STANDARD SOLUTIONS for LIMIT testsEUROPEAN PHARMACOPOEIA [7646-85-7].SeeZinc chloride (0110).Zinc chloride-formic acid 20 g ofzinc chloride Rin 80 g of an 850 g/lsolution ofanhydrous formic acid chloride solution, 20 g ofzinc chloride Rand g ofpotassiumiodide Rin ml ofwater Randshake for 15 min. Filter if iodide and starch a solution of 2 g ofzinc chloride Rin 10 ml ofwater Radd g ofsoluble starch Rand heat until the starch hasdissolved. After cooling to room temperature add ml of acolourless solution containing gzinc Ras filings g ofiodine Rinwater R.

2 Dilute the solution to 100 mlwithwater Rand : protected from for ml ofsodium nitritesolution Rto 50 ml withwater ml ofdilute sulphuric acid Rand ml of the zinciodide and starch solution and mix. The solution [1314-13-2].SeeZinc oxide (0252).Zinc ( ).1096800.[7440-66-6].Content: minimum per cent of Zn ( ).A very fine, grey powder, soluble indilute hydrochloricacid [7446-20-0].SeeZinc sulphate (0111).Zirconyl basic salt corresponding approximatelyto the formula ZrCl2O, [15461-27-5].Content: minimum per cent of ZrCl2O, or almost white, crystalline powder or crystals, freelysoluble in water and in g in a mixture of 5 ml ofnitric acid Rand 50 ml ofwater M silver nitrateand 3 ml ofdibutyl phthalate Rand shake.

3 Using 2 ml offerric ammonium sulphate solution R2as indicator, M ammonium thiocyanateuntil a reddish-yellowcolour is M silver nitrateis equivalent to mg ofZrCl2O, basic salt corresponding approximatelyto the formula ZrO(NO3)2, [14985-18-3].A white or almost white powder or crystals, hygroscopic,soluble in water. The aqueous solution is a clear or at mostslightly opalescent : in an airtight nitrate Rand60 ml ofhydrochloric acid STANDARD SOLUTIONS FORLIMIT TESTSA cetaldehyde STANDARD solution (100 ppm C2H4O). g ofacetaldehyde Rin2-propanol Rand diluteto ml with the same solvent.

4 Dilute ml of thesolution to ml with2-propanol R. Prepare immediatelybefore STANDARD solution (100 ppm C2H4O) g ofacetaldehyde Rinwater Rand dilute ml with the same solvent. Dilute ml of the solutionto ml withwater R. Prepare immediately before STANDARD solution (200 ppm Al). inwater Raquantityofaluminium potassiumsulphate Requivalent to g of AlK(SO4)2,12H2O. Add10 ml ofdilute sulphuric acid Rand dilute to ml withwater STANDARD solution (100 ppm Al). before use, dilute withwater Rto 10 timesits volume a solution containing g ofaluminiumchloride Rin ml ofwater STANDARD solution (10 ppm Al).

5 Before use, dilute withwater Rto 100 timesits volume in a solution containingaluminium nitrate Requivalent to g of Al(NO3)3, STANDARD solution (2 ppm Al). before use, dilute withwater Rto 100 timesits volume a solution containingaluminium potassiumsulphate Requivalent to g of AlK(SO4)2,12H2 Oand10 ml ofdilute sulphuric acid Rin STANDARD solution (100 ppm NH4). before use, dilute to 25 ml withwater R10 mlof a solution containingammonium chloride Requivalentto g of NH4Cl in 1000 STANDARD solution ( ppm NH4). before use, dilute withwater Rto 100 timesits volume a solution containingammonium chloride Requivalent to g of NH4Cl in STANDARD solution (1 ppm NH4).

6 Before use, diluteammonium STANDARD solution( ppm NH4)Rto times its volume withwater STANDARD solution (100 ppm Sb). potassium tartrate Requivalent g of C4H4KO7Sb,1/2H2O in 500 ml of1M hydrochloricacidand dilute the clear solution to 1000 ml withwater STANDARD solution (1 ppm Sb). potassium tartrate Requivalent g of C4H4KO7Sb,1/2H2 Oin20mlofhydrochloricacid R1and dilute the clear solution to ml withwater R. To ml of this solution add 200 ml ofhydrochloric acid R1and dilute to ml withwater ml of this solution add 300 ml ofhydrochloricacid R1and dilute to ml withwater R.

7 Prepare thedilute SOLUTIONS immediately before the information section on general monographs (cover pages)EUROPEAN PHARMACOPOEIA STANDARD SOLUTIONS for LIMIT testsArsenic STANDARD solution (10 ppm As). before use, dilute withwater Rto 100 timesits volume a solution prepared by dissolvingarsenioustrioxide Requivalent to g of As2O3in 5 ml ofdilutesodium hydroxide solution Rand diluting to ml withwater STANDARD solution (1 ppm As). before use, dilutearsenic STANDARD solution(10 ppm As) Rto 10 times its volume withwater STANDARD solution ( ppm As). before use, dilutearsenic STANDARD solution(1 ppm As) Rto 10 times its volume withwater STANDARD solution ( per cent Ba).

8 Chloride Requivalent to g ofBaCl2,2H2 Oindistilled water Rand dilute to ml withthe same STANDARD solution (50 ppm Ba). before use, dilute withdistilled water Rto20 times its volume a solution indistilled water Rcontainingbarium chloride Requivalent to g of BaCl2, STANDARD solution (2 ppm Ba). before use, dilutebarium STANDARD solution(50 ppm Ba) Rto 25 times its volume withdistilled water STANDARD solution (100 ppm Bi). Requivalent to g of Bi in 50 ml ofnitric acid Rand dilute to ml withwater solution to 10 times its volume withdilute nitric acid Rimmediately before STANDARD solution ( per cent Cd).

9 Requivalent to g of Cd in thesmallest necessary amount of a mixture of equal volumes ofhydrochloric acid Randwater Rand dilute to ml witha1percentV/Vsolution ofhydrochloric acid STANDARD solution (10 ppm Cd) . before use, dilutecadmium STANDARD solution( per cent Cd) Rto 100 times its volume with a 1 percentV/Vsolution ofhydrochloric acid STANDARD solution (400 ppm Ca). before use, dilute withdistilled water Rto10 times its volume a solution indistilled water Rcontainingcalcium carbonate Requivalent to g of CaCO3and23 ml of1 M hydrochloric acidin STANDARD solution (100 ppm Ca).

10 Before use, dilute withdistilled water Rto10 times its volume a solution indistilled water Rcontainingcalcium carbonate Requivalent to g of CaCO3and3mlofacetic acid Rin STANDARD solution (100 ppm Ca) before use, dilute withwater Rto 10 times itsvolume a solution containinganhydrous calcium chloride Requivalent to g of CaCl2in ml ofdilutehydrochloric acid STANDARD solution (100 ppm Ca), before use, dilute withalcohol Rto 10 times itsvolume a solution indistilled water Rcontainingcalciumcarbonate Requivalent to g of CaCO3and 12 ml ofacetic acid Rin STANDARD solution (10 ppm Ca).