AACR-Johnson & Johnson Lung Cancer Innovation …

1 AACR-J ohnson & Johnson Lung Cancer Innovation Science Grants 2018 Program Guidelines and Application Instructions American Association for Cancer Research 615 Chestnut Street, 17th Floor Philadelphia, PA 19106-4404 Last Updated: February 21, 2018 TABLE OF CONTENTS PROGRAM SUMMARY ..3 APPLICATION DEADLINE ..3 APPLICANT ELIGIBILITY CRITERIA ..3 RESEARCH PROJECT CRITERIA ..4 OVERSIGHT AND MANAGEMENT ..5 BUDGET STIPULATIONS ..5 EVALUATION OF APPLICATIONS ..5 TOBACCO INDUSTRY FUNDING AND CONFLICTS OF INTEREST STATEMENT ..6 APPLICATION INSTRUCTIONS ..7 APPLICATION PROCEDURES ..7 GETTING STARTED IN proposalCENTRAL ..7 APPLICATION FORMAT.

2 8 SUBMITTING COMPLETE APPLICATION .. 15 CHANGES TO YOUR APPLICATION .. 16 INQUIRIES .. 17 MORE ABOUT THE AACR .. 18 AACR-Johnson & Johnson Lung Cancer Innovation Science Grants 2018 Program Guidelines and Application Instructions Page 3 of 18 PROGRAM GUIDELINES PROGRAM SUMMARY Because of the late onset of clinical symptoms and inadequate screening programs, nearly two-thirds of all lung cancers are diagnosed at an advanced stage and, as a result, five-year survival rates are still below 18%. Interventions at the earliest stages of the disease process while there are no clinical manifestations, or when the tumor is small and localized, improves survival outcomes; therefore, simple yet accurate diagnostic tools that can improve the detection of early lung cancers are urgently needed.

3 The AACR-Johnson & Johnson Lung Cancer Innovation Science Grants represent a joint effort to address this need by promoting and supporting pioneering Cancer research. Proposals should focus on understanding the behaviors that lead to chronic exposures to respiratory carcinogens and how these behaviors can be modified; how chronic exposures produce cellular/genomic damage and how these can be ameliorated; deciphering the types of inflammation that underlie the carcinogenic process; understanding the alterations in innate and adaptive immunity that create an immune-permissive microenvironment; and changes in the pulmonary microbiome that may contribute to carcinogenesis.

4 Proposals that characterize premalignant lesions or that substantially improve the detection of lung Cancer at more curable stages will also be prioritized. This project must be implemented by a multi-institutional team, composed of Principal Investigators from at least two, but no more than three, different institutions. The Grant will provide $ million in funding for direct and indirect expenses related to each research project over a three year timeframe. In addition to the grant, the AACR will provide strategic project management support to help optimize project implementation and progress during the grant term. APPLICATION DEADLINE EXTENDED May 2, 2018, at 1:00 Eastern Time NOTIFICATION OF AWARD June 2018 GRANTS RECEPTION AND DINNER AT AACR ANNUAL MEETING 2019 April 2, 2019 Grant recipients must attend the Grants Reception and Dinner (April 2) to formally accept their grant.

5 Grant funds may be used to support the grantees registration and attendance at this Annual Meeting. START OF GRANT TERM July 1, 2018 APPLICANT ELIGIBILITY CRITERIA At least two, but no more than three, co-applicants serving as co-Principal Investigators (co-PIs) from distinct institutions are required. The team will be directed by the Lead Principal Investigator (Lead PI) who is responsible for the application, disbursement of funds to the various research projects, the conduct of the projects, and progress reporting. Principal Investigators (PIs) must have a doctoral degree (including PhD, MD, DO, DC, ND, DDS, DVM, ScD, DNS, PharmD, or equivalent doctoral degree) in the biomedical sciences or in a field applicable to health science research and not currently be a candidate AACR-Johnson & Johnson Lung Cancer Innovation Science Grants 2018 Program Guidelines and Application Instructions Page 4 of 18 for a further doctoral or professional degree.

6 In addition to the co-PIs, the Project Team should also include at least one young investigator ( , postdoctoral or clinical research fellow; junior faculty member). While not a co-PI, this young investigator should play a key role in the project. Applications will be accepted from independent investigators at all levels who are affiliated with an academic, medical, or research institution anywhere in the world (there are no citizenship or geographic requirements; however, by submitting an application for this grant, an applicant applying from an institution located in a country in which they are not a citizen or a permanent resident assures that the visa status will provide sufficient time to complete the project and grant term at the institution from which they applied.)

7 Employees or subcontractors of a government entity or for-profit private industry are not eligible. Employees or subcontractors of a government entity or for-profit private industry may serve as Collaborators, but no grant funds may be directed towards these individuals. AACR membership is required. Nonmembers interested in this grant opportunity must submit a satisfactory application for AACR Active Membership by Wednesday, May 2, 2018. The application will be applied to 2018 membership dues. Applications may be submitted using the Official Application for Membership online or downloaded as a PDF and submitted to the AACR office with the required documents.

8 Investigators may submit only one application for the AACR-Johnson & Johnson Lung Cancer Innovation Science Grants, but may concurrently apply for other AACR grants. Current AACR Grantees may apply, but must be up to date with all reporting requirements to be considered eligible. Only one application per lead PI will be accepted for the AACR-Johnson & Johnson Lung Cancer Innovation Science Grants, although individuals may serve as a co-PI or contribute to more than one application. Postdoctoral or clinical research fellows or the equivalent who are working under the auspices of a scientific mentor are not eligible to apply. Qualified fellows are invited to apply for an AACR Fellowship.

9 Members of the Scientific Review Committee are not eligible to apply for a AACR-Johnson & Johnson Lung Cancer Innovation Science Grants. All applicants with questions about eligibility should contact AACR s Scientific Review and Grants Administration Department (AACR s SRGA) at before submitting an application. RESEARCH PROJECT CRITERIA Proposals will be accepted for new ideas and innovative approaches that have direct application and relevance to lung Cancer interception. Proposed research projects can be in any discipline including basic, translational, or clinical Cancer research. Proposals should focus on understanding the behaviors that lead to chronic exposures to respiratory carcinogens and how these behaviors can be modified; how chronic exposures produce cellular/genomic damage and how these can be ameliorated; deciphering the types of inflammation that underlie the carcinogenic process; understanding the alterations in innate and adaptive immunity that create an immune-permissive microenvironment; and changes in the pulmonary microbiome that may contribute AACR-Johnson & Johnson Lung Cancer Innovation Science Grants 2018 Program Guidelines and Application Instructions Page 5 of 18 to carcinogenesis.

10 Proposals that characterize premalignant lesions or that substantially improve the detection of lung Cancer at more curable stages will also be prioritized. OVERSIGHT AND MANAGEMENT The project funded by the AACR-Johnson & Johnson Lung Cancer Innovation Science Grants will be directed by the Lead PI. The Project Team is expected to create a comprehensive communication plan detailing how the Team will work together to achieve the Project Aims. Meetings should be held no less than quarterly to evaluate research progress, and can be conducted either by telephone or in face-to-face meetings. The Project Team will also be required to meet with a Grant Program Advisory Committee (GPAC), composed of senior members of Johnson & Johnson and AACR staff, to discuss progress.