Transcription of Clostridium difficile 毒素遺伝子検査を踏まえた検査アルゴリ …
1 Clostridium difficile .. Clostridium difficile (CDI) C. difficile . C. difficile .. C. difficile toxin A toxin B binary toxin 3. C. difficile . C. difficile C. difficile .. C. difficile C. difficile CDI CDI .. CDI . 027 078 . CDI . C. difficile MRSA . Centers for Disease Control and Prevention (CDC) . C. difficile . CDI . CDI .. 1. CDI C. difficile . C. difficile .. C. difficile .. CDI C. difficile .. C. difficile . C. difficile (glutamate dehydrogenase: GDH) . GDH .. 1), 2) . C. difficile . CDI.
2 CDI GDH .. 2 1, 2) . 48. 96 GDH . GDH . 2 .. PCR. Nucleic acid amplification test (NAAT) CDI 2 . NAAT . NAAT CDI.. 2.. CDI . NAAT .. Clostridium difficile . Clostridium difficile NAAT . C. difficile . ACG . European Society of Clinical Microbiology and Infectious Diseases ESCMID 2, 3) .. 1.. 2. C. difficile .. 3. 48 72 .. C. difficile . C. difficile .. Clostridium difficile . C. difficile (CDI) . GDH . C. difficile NAAT .. CDI . NAAT .. 1.. 3. C. difficile CDI . CDI. Bristol Stool Form Scale4).
3 Bristol Stool 5 .. 2. C. difficile 1 . GDH . NAAT . GDH GDH . CDI GDH CDI . GDH .. GDH NAAT. CDI . CDI C. difficile .. 3. C. difficile . 2a, 2b . 1 GDH . NAAT . GDH .. NAAT .. NAAT . NAAT ( . 2a) GDH NAAT ( . 2b) . NAAT C. difficile 4. Over Diagnosis .. 1. Cohen SH, Gerding DN, Johnson S, et al., Clinical practice guidelines for Clostridium difficile infection in adults: 2010 update by the society for healthcare epidemiology of America (SHEA) and the infectious diseases society of America (IDSA).
4 Infect Control Hosp Epidemiol. 2010. May;31(5):431-455. 2. Crobach MJ, Planche T, Eckert C, et al., European Society of Clinical Microbiology and Infectious Diseases: update of the diagnostic guidance document for Clostridium difficile infection. Clin Microbiol Infect. 2016. Aug;22 Suppl 4:S63-81. 3. Surawicz CM, Brandt LJ, Binion DG, et al., Guidelines for diagnosis, treatment, and prevention of Clostridium difficile infections. Am J. Gastroenterol. 2013 Apr;108(4):478-98. 4. Lewis SJ, Heaton KW.
5 Stool form scale as a useful guide to intestinal transit time. Scand J Gastroenterol. 1997 Sep;32(9):920-4. 5.
