CONTENTS

1 3. CONTENTS . v xv USE OF JMPR REPORTS AND EVALUATIONS BY REGISTRATION. 1. 1. 2. GENERAL 3. FAO Manual on the submission and evaluation of pesticide residues data for the estimation of maximum residue levels in food and feed .. 3. Submission of information for consideration by the FAO Panel .. 4. MRLS for pesticides for which JMPR estimates of dietary intake exceed the ADI .. 5. The estimation of maximum residue and STMR levels for products of animal origin when residues are transferred from feed 7. Extrapolation of residue data to minor crops .. 9. Calculation of dietary intake of pesticide residues .. 10. 3. SPECIFIC PROBLEMS .. 13. Harmonisation of recommendations from the JMPR and JECFA for MRLs for pesticides with both agricultural and veterinary uses .. 13. Nature of fat samples in studies on fat-soluble compounds .. 13. Assessment of chronic dietary risk of dithiocarbamate 16. 4. EVALUATION OF DATA FOR ACCEPTABLE DAILY INTAKE FOR HUMANS, MAXIMUM RESIDUE LEVELS, AND STMR LEVELS1.

2 19. Abamectin (T,R) .. 19. Amitrole (T) .. 31. Bifenthrin (R) .. 35. Captan (R) .. 37. Carbofuran (R)** .. 40. Carbosulfan (R)**.. 51. Chlormequat (T).. 63. Chlorothalonil (R) .. 66. 1. T = Toxicology *New compound R = Residue and analytical aspects **Evaluation in CCPR periodic review programme E = Evaluation of effects on the environment 4. Clethodim (R).. 72. 2,4-D and its salts and esters (E).. 81. Ethephon (T).. 86. Fenamiphos (T)** .. 87. Fenbuconazole (T,R)*.. 93. Fenthion (T)..106. Fipronil (T)* ..106. Folpet (R)..118. Glyphosate (T,R) ..125. Guazatine (T,R)**..134. Lindane (gamma-HCH) (T) ..144. Malathion (T)** ..148. Methamidophos (R)..151. Methidathion (T) ..153. Mevinphos (E,R)** ..154. Myclobutanil (R) ..168. Parathion (R)..173. Phosalone (T)..174. Phosmet (R)** ..175. Tebuconazole (R) ..182. Tebufenozide (R)..188. Thiabendazole (R)**..189. Triforine (T)**..199. 5. 6. FUTURE WORK ..207. 1998 1999 7.

3 CORRECTIONS TO REPORT OF 1996 ANNEX I: ADIs, acute RfDs, recommended MRLs, STMRs, ANNEX II: Index of reports and ANNEX III: Intake predictions ..245. 5. 1997 JOINT MEETING OF THE FAO PANEL OF EXPERTS ON PESTICIDE. RESIDUES IN FOOD AND THE ENVIRONMENT AND THE WHO CORE. ASSESSEMENT GROUP. Lyon (IARC), 22 September-1 October 1997. PARTICIPANTS. WHO Members Professor Joseph F. Borzelleca (Unable to attend). Pharmacology, Toxicology Medical College of Virginia Virginia Commonwealth University Box 980613. Richmond, VA 23298-0613. USA. Tel: (1 804) Fax: (1 804) 285 1401. : Dr Penelope Fenner-Crisp Chairman Acting Director Office of Science Coordinator and Policy (7101). US Environmental Protection Agency 401 M Street, Washington, 20460. USA. Tel: (1 202) 260 0947. Fax: (1 202) 260 1847. : Dr Donald L. Grant Rapporteur Director Health Evaluation Division Pest Management Regulatory Agency 6605E. 2250 Riverside Drive Ottawa, Ontario K1A OK9.

4 Canada Tel: (1 613) 736 3510. Fax: (1 613) 736 3505. : 6 Participants Dr Angelo Moretto Istituto di Medicina del Lavoro Universit degli Studi di Padova Via J. Facciolati 71. 35127 Padova Italy Tel: (39 49) 821 6620/6624. Fax: (39 49) 821 6644. Dr Olavi Pelkonen Professor of Pharmacology Department of Pharmacology and Toxicology University of Oulu Kajaanintie 52 D. FIN-90220 Oulu Finland Tel: (358 8) 537 5230. Fax: (358 8) 537 5247. : Dr Brian G. Priestly Scientific Director Chemicals & Non-Prescription Drug Branch Therapeutic Goods Administration Commonwealth Department of Health and Family Services Box 100. Woden, ACT 2606. Australia Tel: (61 2) 6289 7040. Fax: (61 2) 6289 7211. : Dr Peipei Yao Professor of Toxicology Consultant of ICAMA. Institute of Occupational Medicine, CAPM. Ministry of Health 29 Nan Wei Road Beijing 100050. China Tel: (86 10) 6315 3319. Fax: (86 10) 6301 4323. : Participants 7. FAO Members Dr rp d Ambrus Budapest Plant Health and Soil Conservation Station H-1519, Box 340.

5 Budapest, Hungary Tel: (36 1) 309 1016. Fax: (36 1) 246 2942. At present: c/o Joint FAO/IAEA Division Wagramerstrasse 5. A-1400 Vienna, Austria Tel: (43 1) 206 02 6059. Fax: (43 1) 20607. : Dr Ursula Banasiak Federal Biological Research Centre for Agriculture and Forestry Stahnsdorfer Damm 81. 14532 Kleinmachnow Germany Tel: (49 33203) 48338. Fax: (49 33203) 48425. : Mr Stephen Crossley Pesticide Safety Directorate Mallard House, Kings Pool 3 Peasholme Green York Y01 2PX. UK. Tel: (44 1904) 455 903. Fax: (44 1904) 455 711. E-mail: Mr Denis J. Hamilton Rapporteur Principal Scientific Officer Animal and Plant Health Service Department of Primary Industries Floor 3, Primary Industries Building 80 Ann Street Box 46. Brisbane, Queensland 4001. Australia Tel: (61 7) 3239 3409. Fax: (61 7) 3211 3293. 8 Participants E-mail: Mr N. Fred Ives Vice-chairman Health Effects Division (H7509C). US Environmental Protection Agency 401 M Street, Washington, 20460.

6 USA. Tel: (1 703) 305 6378. Fax: (1 703) 305 5147/5529. E-mail: Ms E. Masoller Servicios de Laboratorios Ministerio de Ganader a, Agricultura y Pesca Av. Mill n 4703. Montevideo Uruguay Tel: (598 2) 393 181. Fax: (598 2) 393 181/393 068. Mr T. Sakamoto Head of Technical Research Section Agricultural Chemicals Inspection Station (ACIS). Ministry of Agriculture Forestry and Fisheries 2-772 Suzuki-Cho Kodaira-Shi 187 Tokyo Japan Tel: (81) 423 853 2151. Fax: (81) 423 85 3361. E-mail: Secretariat Dr Eloisa Dutra Caldas (FAO Consultant). Instituto de Sa de do DF/Ger ncia de Bromatologia e Qu mica SGAN Qd. 601 Bl. O/P-70830-010. Bras lia/DF. Brazil Tel: (556 1) 316 9825. Fax: (556 1) 321 9995. E-mail: Participants 9. Dr Peter J. Campbell (WHO Temporary Adviser). Pesticides Safety Directorate Ministry of Agriculture, Fisheries and Food Mallard House Kings Pool 3 Peasholme Green GB-York, YO1 2PX. Tel: (44 1904) 455 910.

7 Fax: (44 1904) 455 711. : Mr David J. Clegg (WHO Temporary Adviser). 142 Corkery Woods Drive Carp, Ontario KOA 1LO. Canada Tel: (1 613) 256 4518. Fax: same as telephone Dr Dewhurst (WHO Temporary Adviser). Pesticides Safety Directorate Ministry of Agriculture, Fisheries and Food Mallard House King's Pool 3 Peasholme Green York YO1 2PX. UK. Tel: (44 1904) 455 890. Fax: (44 1904) 455 711. : Dr Stuart Dobson (WHO Temporary Adviser). Institute of Terrestrial Ecology Monks Wood Abbots Ripton Huntingdon GB-Cambridgeshire PE17 2LS. Tel: (44 1487) 773 381. Fax: (44 1487) 773 467. : 10 Participants Dr van Eck (WHO Temporary Adviser). Chairman, Codex Committee on Pesticide Residues Division of Public Health Ministry of Health Welfare and Sport Postbox 5406. Sir Winston Churchillaan 368. 2280 HK Rijswijk Netherlands Tel: (31 70) 340 69 66. Fax: (31 70) 340 51 77. : Dr Kannosuke Fujimori (WHO Temporary Adviser). Division of Pharmacology Biological Safety Research Center National Institute of Health Sciences 18-1 Kamiyoga 1-chome Setagaya-ku Tokyo 158.

8 Japan Tel: (81 3) 3700 1141. Fax: (81 3) 3707 6950. : Dr Steve Funk (FAO Consultant). Health Effects Division (7509C). US Environmental Protection Agency 401 M Street, Washington, 20460. USA. Tel: (1 703) 305 5430. Fax: (1 703) 305 5147/5529. E-mail: Dr Susanne Geertsen (WHO Temporary Adviser). Insecticide Toxicological Evaluation Section Health Evaluation Division Pest Management Regulatory Agency Sir Charles Tupper Building, Room E607. 2250 Riverside Drive Address Locator: 6606E1. Ottawa, Ontario K1A OK9. Canada Tel: (1 613) 736 3645. Fax: (1 613) 736 3505. : Participants 11. Professor Jana Hajslova (WHO Temporary Adviser). Institute of Chemical Technology Department of Food Chemistry and Analysis Technick 3. 16628 Prague 6. Czech Republic Tel: (420 2) 243 53185. Fax: (420 2) 243 14096. : Dr Karen L. Hamernik (WHO Temporary Adviser). Toxicology Branch II. Health Effects Division Office of Pesticide Programs US Environmental Protection Agency 401 M Street, (7509C).

9 Washington, 20460. USA. Tel: (1 703) 305 5467. Fax: (1 703) 305 5147. : Dr John L. Herrman WHO Joint Secretary Assessment of Risk and Methodologies International Programme on Chemical Safety World Health Organization 1211 Geneva 27. Switzerland Tel: (41 22) 791 3569. Fax: (41 22) 791 4848. : Mrs Elisabeth Heseltine Communication in Science Lajarthe 24290 Saint-L on-sur-V z re France Tel: (33 553) 50 73 47. Fax: (33 553) 50 70 16. : 12 Participants Mrs Paula H. van Hoeven-Arentzen (WHO Temporary Adviser). Centre for Substances and Risk Assessment National Institute of Public Health and the Environment Antonie van Leeuwenhoeklaan 9. Box 1. 3720 BA Bilthoven The Netherlands Tel: (31 30) 274 32 63. Fax: (31 30) 274 4401. : Dr Kopisch-Obuch FAO Joint Secretary Senior Officer Pesticide Group Plant Protection Service Food and Agriculture Organization of the United Nations Viale delle Terme di Caracalla 00100 Rome Italy Tel: (39 6) 570 55757.

10 Fax: (39 6) 570 56347. : Dr Douglas McGregor Unit of Carcinogen Identification and Evaluation International Agency for Research on Cancer 150 cours Albert-Thomas 69372 Lyon Cedex 08. France Tel: (33) 72 73 84 85. Fax: (33) 72 73 85 75. : Dr Jens-J. Larsen (WHO Temporary Adviser). Head, Department of General Toxicology Institute of Toxicology Danish Veterinary and Food Administration M rkh j Bygade 19. DK - 2860 S borg Denmark Tel: (45 33) 95 60 00. Fax: (45 33) 95 66 96. : Participants 13. Mr Machin (FAO Consultant). Boundary Corner 2 Ullathorne Road London SW16 1SN. UK. Tel: (44 181) 769 0435. Fax: same as telephone : (c/o) Dr Timothy C. Marrs (WHO Temporary Adviser). Medical Toxicology and Environmental Health Department of Health Skipton House, Room 683D. 80 London Road Elephant and Castle GB-London SE1 6LW. Tel: (44 171) 972 5328. Fax: (44 171) 972 5134. Dr Gerry Moy Programme of Food Safety and Food Aid World Health Organization 1211 Geneva 27.