Corynebacterium durum 1 - jscm.org

1 +z "W, 2007 1.. Corynebacterium durum 1 . 1) 2) 3) 4) 1) 3). 1). !". 2). # $ % ! & '()*. 3). +! , , -,./"0"# $',12 3% ',# . 4). 456". 789 JA :"&;':" 456"<. 7() 18 * 3 = 27 +,-> () 18 * 11 = 6 +,.<. ?@A> BCDE/ F01 Corynebacterium durum 1. GHI J K2A 65 L> 3J () 5 *MNO4G5 PBCDE/ 6 F Q7. G,R S J () 14 * 11 = 12 +8 456"T9G,: > BCDE/ Q7;<F. > U => V4=WXG>? T9F HYZ[ S J () 15 * 10 = 17 +> \@ A. BF]S P9 ^. C4DE FG^. J C4 _`* HabAIJ KOc dF. Nocardia LFMN #+ _`*O3P GIJZ[ > e X Q e CT fghR S. Y3 ThiE/ BCDUjF#VWXYG5 Pkl > mZ U = [\WnoG. p^WSl WXab Nocardia LFMk& G S]Q-F&^> q r sulfamethoxa- zole-trimethoprim 7ST %s< FMkQ7 tu^. J DEab 3 +;F1v w xy z)f_` !Ga{ l|> }~_` !fA Nocardia asteroides _`^.]

2 > . 5 PF 16S rRNA ) bG o> cf C. durum _`^. J. Key words: Corynebacterium durum > BCDE/ > #+ _`*O3P > Nocardia>. Kinyoun H. A> UTGw v W > x y Corynebacterium durum A> d<F Nocardia L F ^. v WafA 5 #n . i Actinomyces Le fQ gFg k_`*O f k6)J z{fA?@ | fAz . 3P f kJ Corynebacterium L A diphtheria }v WkJ. toxin G " k C. diphtheriae, C. ulcerans TA. + & > hB iij> klWX I.. ^ W mab#n^. kJ > * o 1. K29 65 L> 3. 2 ph3 i> qO WX^ W+ & 2. ]~9 \@> O4G C4 . r;Gs > ^bFU =Ft u3 3. 9 +\ 7 <> > h 3 T. Gp w Skl v ^. Sk1 5)J > )3 . a > ?@ #n C. durum 4. 9 M wl W . 5. 8 9 () 5 *FO4G5P6 G,:J g [2&^ 9 ( 076 8765) 13 1 hR BCDE/ : ^. > Q7G,R .. S J q r() 14 * 11 = 12 +F . !". P8 456"T9G,: > +().. TEL: 0167 23 2181 7UQ 227< 14 * 11 = 13 +MNBCDE/ Q7G.

3 FAX: 0167 39 1077 k P W J () 15 * 10 = 17. E-mail: +> \@ ABF]S P09 ^. J. +z "W, Vol. 17 No. 1 2007. 1. 2 .. 6. 15 & F &4< . 10 17 130/88 mmHg, 15 10 17 . ! "# n7 . $% & '. 7. ()*+ 15 10 17 , . 0()123$% & ' $4$ 5. 67 89 :;< =$ . 10 17 >? @ A1B< C. 9 :;< DE4F G H I JK ' L MNOP 14 11 13 . QR$ MN X S TU 1V MN CT TU 2V. EWX$% 15 10 17 QR$ . MN X S TU 3V : YGZ[ \]9^G . MN CT TU 4V : YG _`abcd . efgh 1i ZI jk '. 8. lm] 14 11 13 n MN. X S %YG _`abP1i o B p carbocisteine q r ' 12 . 11 st +F & clarithro- mycin (CAM) 1 1 u 200 mg 28 v w x1yz$ ' CAM wx1yz{|E }. n ~ $ st1i U 2. MN CT . 6. : w & 14 11 13 n MN CT' Y. G _`abP1i |'. & <%n F ' 4F 1 v n ;|o U 1. MN X S . 6 U 3. MN X S . 14 11 13 n M N X S' 15 10 17 $% MN X.

4 YGZ[ _`abP1i |' S' YGZ[ \]9 ^G$% |'. 2 l /g0 Vol. 17 No. 1 2007. Corynebacterium durum Rs o 1 3. * 6. &' CT %. :; 16 < 1 = 14 8 ST 5623% &'. CT# _ . * 4. &' CT .% J #. : ; 15 < 10 = 17 8 . / 0 & '. CT# _ . J rW #.. Nocardia . !" # $ % &' X ( )* 3+ &' CT. )* 4+ ,- ./ 0 1 CAM 2. 3 4 sulfamethoxazole-trimethoprim )ST 56+ 1 7 2 g 1 8 2 7 28 8923 . # ST 5623% :; 16 < 1 = 14 8>? @ ABC DEF G HIJKL M. NJOD PQRSATUVWXY" J&'. X ( )* 5+ &' CT )* 6+ Z [\ . #. 9. ]^_`aRSb i) cdefRRSb ghTU PQRS1A. carbocisteine 23ijklRm1O" . no pqrW . ARsVWXY". # Y :; 15 < 10 = 17 8 EFRS1. A t F )Miller & Jones u1 P2 vw+. JxsVWyz{|} G ~ F {. )8 + TU # . * 5. &' X ( %. 1A * 7 No- :; 16 < 1 = 14 8 ST 5623% &'.]}

5 X (# J[\ cardia . # # Vr Nocardia . 1 1 1 . )Kinyoun + TU . 8 ]^_` Vol. 17 No. 1 2007. 3. 4 IJKLMNOPQMNRSTM UVWMXYZ[\M]^_`. 7. Gram 1000 8. Kinyoun 1000 Nocardia &' () *+ ,- () . !"#$% !"#$%. 9../0 12 C. durum 345 3 67 89:;% ' <= 89:; 12>!?$%. 4 6@ABCDEFGH Vol. 17 No. 1 2007. Corynebacterium durum C T 1 U 5. 8 C. durum " mannitol zqr <. Nocardia C. matruchotii " z Api Coryne 98 KL" O . ii) !" 5# $%& M} rKL 8rbO"9s I . ' ( ) *+, ' ( I C. matruchotii = " C. ) ' ( ) 7 durum O> qrP "P b 3589:; <= 18 >? OI 2 9sr u vw# 5 /98. @ A 14 11 B 16 C 9 Nocardia O C. du- "DE FG < H I I rum r g & ? b- I A 15 10 B 17 9"J galactosidase 9trbO @ 6) ^ K. KLI Nocardia H M L v w # 5 / M b- 9 5#.

6 $%& *+, galactosidase " | o-Nitrophenyl-b-9- N OP 2 galactopyranoside r Rap ID CB Plus Q mm 3 Q 2 mm 9 " 2-Naphthyl-b-galactopyranoside R! STU V WXYZ r Api Coryne 9P O KL . [ ,\]. H ^ ,\]. 8 AB C. durum b-galactosidase 5# $%& 9_ ' 9) `Sa " O r 9 e ONPG . Ob "cd " ` 4x ' ( ) b-galactosidase . Sa" e KL O 9P Nocar- iii) # ! J $ KLI ! %f dia 2 . Nocardia # O Nocardia g& iv) Z ! CD Nocardia . hijk& *\lk& 4 Z ! ST eryth- m.*& 5nk*k& 'OP romycin (EM), imipenem / cilastatin (IPM /. BBL) '()o p * qr CS), E 3 F cephem O t . O N. asteroides O* 9s I b 9 D 97 M r Z . # +"t u9vwg&9tr 16S 3 PMIC 31 J, NMIC 5 J ' DADE BE- rRNA PCR +9,- HRING) t M. = {|/0 } MIC G ^ KL" EM 4 mg/. KL # C.

7 durum O~1 Nocardia ml MIC H9t ^ I 9. 2 3 C. durum C O " : Z J KL . 4 @ KLI ST MIC " 2/38 mg/ml O : . C. durum e qr hm Z u MI 7 M . S . i Api Coryne (Bio Merieux) O CAM MIC H" 4 mg/ml ON 9 'O. Rap ID CB Plus ' a,) . KL " Api Co- O 1. Corynebacterium durum . ryne Pro le Code " 3040105 O Rap Z KL. ID CB Plus Pro le Code " 7504041 O P MIC ( mg/ml). P# 679t vw# 5 Cefotaxime 8. / 8 " . { 5 Ceftazidime 8. pyrazinamidase, glucose, sucrose, Cefpirome 2. " ) 6 94 M rP O Cefepime 1. Cefozopran 1. #9 5 I maltose 5 . Flomoxef 1. z :" r ; Sulfamethoxazole-trimethoprim 2/38. C. durum tr C. matruchotii P Imipenem/Cilastatin C. durum O # 9 5 q 9 Erythromycin 4. mannitol K L O r b O O Clarithromycin 4.}

8 AQ R S Vol. 17 No. 1 2007. 5. 6 v 1 l . ^_ L 2 rs b] #Q , . II. FGJ: C. durum ' t A# , . Corynebacterium ' Philippe fy6) N W t2% . C. diphtheriae . ! " Y# L # ^_ Nocardia ] , . #. $% & ' # ( ) *+ 1 C. durum u % # : b- # , !- - " . galactosidase ' X b ]. - / 01% 2' 135) 4 5 b # g ONPG A L , b- * ,6789 ' :; <=# C. durum galactosidase vd v N W . ' 6789 > !" #> w # : L Api Coryne Pro le ?" #>' :$+ %&@ABC D. 6'( Code C. durum ,fy , g !") *E " #> ?" #> , # 8) # , x Pro le Code . +,=F#-* . !- G/ H . 01 I " #J ,6''23 4K L 5 b]#= # M - N:6 6789 '7O% 7). d 4 UVC : #J ,i Tjk J , 6789 +,F / H- ' G_ QR= J IcJ\K . *'?" #> PQ ,RS 1 ' C. MN@\d#y z \K L , \ QR\. durum T 89 , '8) UVC d ef b]\d# , \ ] W5 X % X)<= > ) W5 ^) z{ n , : [ ;'a 2.}

9 CT 9 678# ?@ AB CY 1 | b] " b]' 2 " . Z #0[ RS & '\7 1 #} ,\d , 1 '.# l . " #J - ] ' DE .. ^_ F` GDJ: 1 HZ" , # III.. J - ] 'a ' b$#IcJ\K \~ Nocardia bJ ^) :;. L ,MN@\d ef , 1 O n iq :#g n Yb]#xc ..'P g RS G_ QR\ # b]% = # ) . d= hST i T UV#J: W jX'CY }jT no# #2l ' L ST. , =F g : QR\d ef% #k 2 -4 'q Y W jX CY . l =F RS 1 ' . UVC :#J , m UVCY Z C. Y =[ Nocardia \] 1 #Q , . Nocardia # ^) m ; n ,o: p 1) 1995. +. C Y Kinyoun :#o ,gEiq n #oK Corynebacterium striatum ) <[. , Nocardia _E \d `Y 1 MN@ 5: 22 26. Pa `\drstu l l 'v b 2) 5 r 2000.. ]\d fv 1w , QRgxc Corynebacterium amycolatum #J IVH. :UVC : de fy% z' - 1 MN@ 10: 51 55. d{ 3) v 5 1998. Coryne- bacterium pseudotuberculosis #J 1.

10 UVC : Kinyoun : gQ :h. 6. MN@ 8: 240 245. 789 # Nocardia 'iO% ' 9) 1. 4) 1997. " |}~# Nocardia i Tjk#Q. Corynebacterium striatum ) & ) . ,l 1w mPnoT ,Mp K ~ \d 46: 995 999. , ST 2 UV' )# ST 2. 5) 1994. Cory- '<[}j# L T 1 nebacterium jeikeium #J 1 - . T -4 \d 'q 1 . 'O 68: 1527 1532. 6 MN@ Vol. 17 No. 1 2007. Corynebacterium durum JKL0=)M 1 > 7. 6) Riegel, P., R. Heller, G. Prevost, et al. Oct. 1997. Clinical Microbiology, 8th ed. (P. R. Murray, E. Corynebacterium durum sp. nov., from Human J. Baron, J. H. Jorgensen, et al. ed.), American Clinical Specimens. p. 1107 1111, In: Interna- Society for Microbiology,Washington, tional Journal of Systematic Bacteriology. 9) !"# $%&"' ( 2002.]