医学細菌学上重要なCorynebacterium属 ... - jscm.org

1 2012 corynebacterium 207.. corynebacterium .. 24 8 17 . corynebacterium . Cory- nebacterium .. Key words: corynebacterium , . I.. corynebacterium 2012 8 list of corynebacterium . prokaryotic names with standing in nomenclature (LPSN) corynebacterium Coryne; . 110 11 bacterium; .. corynebacterium vaginale Arcanobacterium, Bre- Gardnerella vaginalis Coryne- vibacterium, Erysipelothrix, Dermabacter, Rothia, Micro- bacterium haemolyticum corynebacterium pyogenes bacterium, Turicella, Oerskovia, Curtobacterium . Arcanobacterium C. pyogenes Ac- corynebacterium . tinomyces pyogenes corynebacterium equi . Rhodococcus equi, corynebacterium acnes Propi- . onibacterium acnes corynebacterium spp.. 1980 Arthrobacter, Clavibacter, Coryne- Curtobacterium Rhodococcus form bacteria .. 1980 . corynebacterium .. II. corynebacterium . corynebacterium 22 36 .. (m-DAP) . 296 8602 929 C. amycolatum, C.

2 Atypicum C. kroppenstedtii .. (C16 : TEL: 04 7099 2324 (DI). FAX: 04 7099 1196 0) (C18 : 1w9c) (C18 : 0). E-mail: (CFA) 1, 2 . Vol. 22 No. 3 2012. 1. 208 . (TBSA) C. urealyticum 5 . 37 18 1 . 2 mm .. 5 . (Lipophilic) Tween80 .. 2. C. ulcerans .. corynebacterium 2001 2 . C. ulcerans . C. diphtheriae, C. ulcerans, C. jeikeium, C. urea- 3 . lyticum, C. resistens, C. striatum, C. pseudodiphtheriti- 4 5 . cum, C. kroppenstedtii, C. amycolatum . 1 20 .. III. corynebacterium 5 37 24 . 1. C. diphtheriae group gravis, mitis, intermedius 1 2 mm .. 1990 C. diphtheriae . 1992 1999 . 68 1 21, 22 . 1999 . C. diphtheriae . C. ulcerans 3. C. striatum . m, AIDS .. 6 10 . 5 37 24 . 1 mm . CNS . Coryneform bacteria .. 2 Vol. 22 No. 3 2012. corynebacterium 209. CAMP 8. C. riegelii 4. C. pseudodiphtheriticum 1998 Funke 27 .. 94 20 . 14 16 . 5 37 48 . 1 2 mm 5 . 37 24 . 48 mm . - .. 5. C. pseudotuberculosis 5.

3 C. diphtheriae .. 23, 24 9. C. jeikeium 1 . 1 25 . 5 37 24 . 1 mm 11 .. C. ulcerans CAMP 28, 29 Corynebacteri- um . 6. C. amycolatum .. 5 37 24 . 48 . C. xerosis, C. striatum, C. minutissimum mm . 1, 27 . 5 37 24 . 1 2 mm . - 10. C. urealyticum . 30 . 7. C. minutissimum .. 1996 . 31 . 26 C. jeikeium . 5 37 24 5 37 . 1 mm 24 48 . mm .. Vol. 22 No. 3 2012. 3. 210 . API CO- 11. C. resistens RYNE . 2005 13 .. corynebacterium . 13, 29 36, 37, 39 .. C. jeikeium . 5 . 37 24 . 48 mm .. 5 10.. 12. C. kroppenstedtii .. 32, 33 2 19, 34 1 corynebacterium spp.. 5 . 37 24 mm . 48 mm 2.. 13. C. macginleyi . 29, 39 Ca, Mg . 5 . 35 35 24 48 48 . 5 24 . 37 24 mm 48 . 24 .. IV. corynebacterium .. 1. MIC (mini- mum inhibitory concentration) .. Coryneform bacteria .. V.. corynebacterium .. RapID CB Plus system Corynebacte- 4 Vol. 22 No. 3 2012. 1. corynebacterium spp.. F CAMP.. O . C. diphtheriae F.

4 Biotype intermedius C. ulcerans F REV . C. striatum F V V . C. pseudodiphtheriticum O V . C. pseudotuberculosis F V V V REV . C. amycolatum F V V V V . C. minutissimum F V V . C. riegelii F V V ( ) . C. jeikeium O V . C. urealyticum O V . C. resistens F . C. kroppenstedtii F V . C. macginleyi F V . corynebacterium .. 1 V REV CAMP . Vol. 22 No. 3 2012. 5. 211. 212 . rium 14) Manzella, J. P., J. A. Kellogg, K. S. Parsey. 1995. Cory- nebacterium pseudodiphtheriticum a respiratory tract pathogen in adults. Clin. Infect. Dis., 20: 37 40.. 15) Ahmed, K., K. Kawakami, K. Watanabe, et al. 1995. corynebacterium pseudodiphtheriticum: a respiratory tract pathogen. Clin. Infect. Dis. 20: 41 46. 16) Freeman, J. D., H. J. Smith, H. G. Haines, et al. 1994. Seven patients with respiratory infections due to Co- rynebacterium pseudodiphtheriticum. Pathology 26: . 311 314. 1) Funke, G., K. A. Bernard.

5 2011. Coryneform Gram- 17) 2000.. positive rods. p. 413 442, In: Manual of clinical mi- corynebacterium amycolatum IVH . crobiology 10th ed. (P. R. Murray, ed), American So- 1 10(1), 51 55 . ciety for Microbiology, Washington, 18) 2004.. 2) Funke, G., A. Graevenitz, J. E. Clarridge, et al. 1997.. Clinical microbiology of coryneform bacteria. Clin. 53: 22 27 . Microbiol. Rev. 10: 125 159. 19) 2012.. 3) Hatanaka, A., A Tsunoda, M. Okamoto, et al. 2003. corynebacterium kroppenstedtii . corynebacterium ulcerans diphtheria in Japan. Emerg- 1 22(2): ing Infectious Diseases 9(6): 752 753. 161 166 . 4) 2006.. 20) Matsunami, M., O. Yoshihito, O. Kiyofumi, et al.. 2011. Urosepsis caused by Globicatella sanguinis and 1 IASR 27: 124 125 . corynebacterium riegelii in an adult: Case report and 5) 2008.. literature review J. Infect. Chemother., Online . FirstTM, 12 November . 1 82: 552 553.

6 21) 1998 . 6) 1997.. corynebacterium striatum . 1992 IASR 19(10), October. 46: 995 999 . 22) 1999 . 7) 1995.. IASR. corynebacterium striatum . 1 5(4): 22 26. 20(12), December. 8) Tarr, P. E., F. Stock, R. H. Cooke, et al. 2003. Multi- 23) Pascual, C., P. A. Lawson, J. A. Farrow, et al. 1995. drug-resistant corynebacterium striatum pneumonia Phylogenetic analysis of the genus corynebacterium in a heart transplant recipient. Transplant Infectious based on 16S rRNA gene sequences. Int. J. Syst. Bac- Disease 5: 53. teriol. 45: 724 728. 9) Prescott, P. L., A. F. Donald, Jr., A. S. Felix 2005. Co- 24) Ruimy, R., P. Riegel, P. Boiron, et al. 1995. Phylogeny rynebacterium striatum: an underappreciated com- of the genus corynebacterium deduced from analy- munity and nosocomial pathogen. J. Infection 50: ses of small-subunit ribosomal DNA sequences. Int. 338 343. J. Syst. Bacteriol. 45: 740 746.

7 10) Renom, F., M. Garau, M. Rubi, et al. 2007. Nosoco- 25) 1998. Coryne- mial outbreak of corynebacterium striatum infection bacterium pseudotuberculosis 1 . in patients with chronic obstructive plumonary dis- 8(3), 62 67 . ease. J. Clin. Microbiol. 45: 2064 2067. 26) Zinkernagel, A. S., A. von Graevenitz, G. Funke. 11) 1994. Cory- 1996. Heterogeneity within corynebacterium minu- nebacterium jeikeium 1 tissimum strains is explained by misidentified Cory- 68: 1527 1532 nebacterium amycolatum strains. Am. J. Clin. Pathol. 12) Otsuka, Y., K. Ohkusu, Y. Kawamura, et al. 2006. 106: 378 383. Emergence of multidrug-resistant corynebacterium 27) Funke, G., P. A. Lawson, M. D. Collins. 1998. Cory- striatum as a nosocomial pathogen in long-term nebacterium riegelii sp. nov., an unusual species iso- hospitalized patients with underlying diseases. lated from female patients with urinary tract infec- Diagn.

8 Microbiol. Infect. Dis. 54: 109 114. tions. J. Clin. Microbiol. 36: 624 627. 13) Otsuka, Y., Y. Kawamura, T. Ezaki, et al. 2005. Cory- 28) Traub, W. H., Geipel. U., Leonhard. B., et al. 1998. nebacterium resistens sp. nov., a new multidrug-resis- Antibiotic susceptibility testing (agar disk diffusion tant Coryneform Bacterium isolated from human in- and agar dilution) of clinical isolates of Corynebacte- fections. J. Clin. Microbiol. 43: 3713 3717. rium jeikeium. Chemotherapy 44: 230 237. 6 Vol. 22 No. 3 2012. corynebacterium 213. 29) 2012. Cory- corynebacterium macginleyi has to date been isolat- nebacterium Erysipelothrix rhusiopathiae ed exclusively from conjunctival swabs. J. Clin. Mi- 22(2), crobiol. 36: 3670 3673. 120 125 36) Funke, G., K. Peters, M. Aravena. 1998. Evaluation 30) Soriano, F., J. M. Aguado, C. Ponte, et al. 1990. Uri- of the RapID CB Plus System for Identification of nary tract infection caused by corynebacterium Coryneform Bacteria and Listeria spp.

9 J. Clin. Mi- group D2: report of 82 cases and review. Rev. Infect. crobiol. 36: 2439 2442. Dis. 12: 1019 1034. 37) Funke, G., F. N. R. Renaud, J. Freney, et al. 1997. 31) 2009. Cory- Multicenter evaluation of the updated and extended nebacterium urealyticum API (RAPID) Coryne Database J. Clin. Microbi- 1 ol. 35: 3122 3126. 83(6): 752 753 38) Y. Otsuka, Y. Kawamura, Y. Yamaguchi, et al. 2006. 32) Riegel, P., P. Liegeois, M. P. Chenard, et al. 2004. Iso- Antimicrobial susceptibility and API CORYNE pro- lations of corynebacterium kroppenstedtii from a file code for 34 strains of the newly reported Coryne- breast abscess. Int. J. Med. Microbiol. 294: 413 416. bacterium resistens, 16th European Congress of Clini- 33) Kieffer, P., R. Dukic, M. Hueber, et al. 2006. A young cal Microbiology and Infectious Diseases. Nice, woman with granulomatous mastitis: A Corynebac- France, April. teria may be involved in the pathogenesis of these 39) Clinical and Laboratory Standards Institute.

10 2006. disease. Rev. Med. Intern. 27: 550 554. Methods for antimicrobial dilution and disk suscep- 34) 2008. Co- tibility testing of infrequently isolated or fastidious rynebacterium kroppenstedtii bacteria; approved guideline, CLSI document M45- 1 69: 3069 3073. A. Clinical and Laboratory Standards Institute, 35) Funke, G., M. Pagano-Niederer, W. Bernauer. 1998. Wayne, Pa. Laboratory Procedure of the Genus corynebacterium Bacteria Which Is Important in Clinical Bacteriology Yoshihito Otsuka Laboratory Medicine, Kameda Medical Center The genus corynebacterium bacteria are one of the difficult bacteria to analysis in clinical laboratories. Recently, de- tection significance of the genus corynebacterium as clinical bacteriology has been clearing because we can identify the bacteria exactly with remarkable development of molecular biology. This review is described that current status and lab- oratory procedure about virulence strain and opportunistic bacteria in Japan.