Description and Solubility - A - DrugFuture

1 5350 Description and Solubility / Reference TablesFirst Supplement to USP 35 NF 30 Description AND SOLUBILITYD escription and Relative Solubility of USP and NF ArticlesThe Description and Solubility statements pertainingand other particulate matter, unless limited or excluded byto an article (formerly included in the individual mono-definite tests or other specifications in the individualgraph) are general in nature. The information is those who use, prepare, and dispense drugs, solely toAbacavir Sulfate:White to off-white powder. Soluble inindicate descriptive and Solubility properties of an articlewater, in ethyl acetate, in absolute alcohol, and in metha-complying with monograph standards.

2 The properties in themselves standards or tests for purity even thoughAcacia:Is practically odorless and produces a mucilagi-they may indirectly assist in the preliminary evaluation ofnous sensation on the tongue. Insoluble in alcohol. Opticalthe integrity of an varies depending on the source of Acacia. For ex-ample, specific rotation values, calculated on the anhydrousTaste and Odorbasis and determined on a (w/v) solution, usually arebetween -25 and -35 for Acacia senegal and between+35 and +60 for Acacia seyal. NF category: EmulsifyingOrganoleptic characteristics are indicated in many in-and/or solubilizing agent; suspending and/or viscosity-in-stances because they may be useful and descriptive proper-creasing agent; tablet of substances.

3 However, they are not meant to be ap-Acebutolol Hydrochloride:White or almost white,plied as tests for identifying powder. Soluble in alcohol and in water; veryThe inclusion of odor or taste among other descriptiveslightly soluble in acetone and in methylene chloride; practi-properties may aid in identifying the causative agent follow-cally insoluble in ether. Melts at about 141 to 144 .ing accidental exposure to or contact with a substance. Thisinformation is provided as a warning or to make an individ-Acesulfame Potassium:A white, crystalline powder orual aware of sensations that may be encountered.

4 The usecolorless crystals. Soluble in water; very slightly soluble inof odor or taste as a test for identification or content isacetone and in alcohol. NF category: Sweetening :White, odorless, crystalline powder,The characteristic odor of a volatile substance becomeshaving a slightly bitter taste. Freely soluble in alcohol; solu-apparent immediately on opening a container of it. Theble in boiling water and in 1N sodium may be agreeable ( , Peppermint Oil), unpleasantAcetazolamide:White to faintly yellowish-white, crys-( , Sulfur Dioxide), or potentially hazardous on prolongedtalline, odorless powder.

5 Sparingly soluble in practically boil-exposure ( , Coal Tar). Moreover, an unexpected odoring water; slightly soluble in alcohol; very slightly soluble inmay be encountered if the characteristics of a substance known or if a container is incorrectly labeled. Conse-Acetic Acid:Clear, colorless liquid, having a strong,quently, containers of such substances should be openedcharacteristic odor, and a sharply acid taste. Specific gravitycautiously, preferably in a well-ventilated fume hood. Ais about Miscible with water, with alcohol, and withcharacteristic taste or sensation produced in the oral cavityglycerin.

6 NF category: Acidifying agent; buffering is apparent if traces of residue materials on fingersare inadvertently brought into contact with the tongue orGlacial Acetic Acid:Clear, colorless liquid, having aadjacent mucosal , characteristic odor and, when well diluted withwater, an acid taste. Boils at about 118 . Specific gravity isabout Miscible with water, with alcohol, and withSolubilityglycerin. NF category: Acidifying :White, crystalline, practically odorlessOnly where a special, quantitative Solubility test is givenpowder. Soluble in pyridine and in dilute solutions of alkaliin the individual monograph, and is designated by a testhydroxides; slightly soluble in alcohol and in chloroform;heading, is it a test for insoluble in water and in approximate solubilities of Pharmacopeial and Na-Acetohydroxamic Acid:White, slightly hygroscopic,tional Formulary substances are indicated by the descriptivecrystalline powder.

7 Melts, after drying at about 80 for 2 toterms in the accompanying table. The term miscible as4 hours, at about 88 . Freely soluble in water and in alco-used in this Pharmacopeia pertains to a substance thathol; very slightly soluble in a homogeneous mixture when mixed in any propor-Acetone:Transparent, colorless, mobile, volatile liquid,tion with the designated a characteristic odor. A solution (1 in 2) is neutral tolitmus. Miscible with water, with alcohol, with ether, withParts of Solvent Requiredchloroform, and with most volatile oils. NF category: Termfor 1 Part of SoluteAcetylcholine Chloride:White or off-white crystals orVery solubleLess than 1crystalline powder.

8 Very soluble in water; freely soluble inFreely solubleFrom 1 to 10alcohol; insoluble in ether. Is decomposed by hot water andSolubleFrom 10 to 30by solubleFrom 30 to 100 Acetylcysteine:White, crystalline powder, having aSlightly solubleFrom 100 to 1000slight acetic odor. Freely soluble in water and in alcohol;Very slightly solubleFrom 1000 to 10,000practically insoluble in chloroform and in insoluble, orAcetyltributyl Citrate:Clear, practically colorless, oilyInsoluble10,000 and overliquid. Freely soluble in alcohol, in isopropyl alcohol, in ace-tone, and in toluene; insoluble in water.

9 NF category:Soluble Pharmacopeial and National Formulary articles, brought into solution, may show traces of physicalAcetyltriethyl Citrate:Clear, practically colorless, oilyimpurities, such as minute fragments of filter paper, fibers,liquid. Freely soluble in alcohol, in isopropyl alcohol, in ace-Official from August 1, 2012 Copyright (c) 2012 The United States Pharmacopeial Convention. All rights from by nEwp0rt1 on Tue Jun 12 00:17:51 EDT 2012 First Supplement to USP 35 NF 30 Reference Tables / Description and Solubility5351tone, and in toluene; insoluble in water.

10 NF category:col; practically insoluble in ethanol and in :Yellow or greenish, crystalline powder. Spar-Alfentanil Hydrochloride:White to almost white pow-ingly soluble in tetrahydrofuran; slightly soluble in acetoneder. Freely soluble in methanol, in alcohol, and in chloro-and in alcohol; very slightly soluble in cyclohexane; practi-form; soluble in water; sparingly soluble in acetone. Meltingcally insoluble in range, crystals from acetone: 136 143 (anhydrous)and reported as crystals from aqueous hydrochloric acid:Acyclovir:White to off-white, crystalline powder.