Transcription of Human T cell development - Abcam
1 TCR rearrangementTCR ,- rearrangementPro Tcell(DN1)CD10-/+CD7-/+CD135CD34CD10-/+C D7-/+CD135CD34T cell(DN2)CD7++CD5CD34 TCR selectionMARROWTHYMUSBLOODMHC selectionApoptosisApoptosisCD7++CD1 ACD34T cell(DN3)CD8 -/+CD1 ACD4T cell(ISP)CD8 -/+CD1 ACD28CD71CD4 Pre-TCRCD1AT cell(preDP) / T cellCD8 / TCR (V 24) / TCRCD4CD8 -/+ / TCRCD4-/+CD3CD3ID3highPLZFIL15IL7 STATsBCL11 BNOTCH1 NOTCH, BCL11B, GATA3,TCF, SCF, IL7 (FLT3L)FOXP3 RAG1,2 NOTCHE2 AHEBGATA3 PTCRA (pT )TCF1 LEFROR TGATA3 TCF1ID3lowRUNX1 HEBRAG1,2 GATA3 RUNX1E2 AHEBGATA3TH-POKMYBIFN , T-BET, STAT4, IL12, RUNX3IL4, GATA3, IL10, STAT6IL6, ROR T, IL23, IL1 , STAT3 TGF , FOXP3 STAT5IL15IL2IL7 STAT5 RUNX3 Pre-TCR / TCRTCR rearrangementNKTcellCD8 -/+CD28CD4-/+CD3CD45 ROCD45 RACD56CD1D selection on DP thymocytesSLAM/SAP signalingMHC-II selected / TCRT regcellCD25CD4CD3CD31 / TCR / TCRTC cellCD8 CD3CD45RA- SelectionHigh MHC affinity+ SelectionIntermediate MHC affinity- SelectionNo MHC affinityCD1 AMHC-IIMHC-ICD69CD3CD69CD27CD27 MHC-IIMHC-ICD3 THcellCD3CD4 / TCRCD45 ROTH 2cellCD3CD4 / TCRCD45 ROTH 1cellCD3CD4IL12R / TCRCD45 ROTH 17cellCD3CD4IL23 RCCR4 CCR6 (CD196)
2 CD161 / TCRCD45 ROTregcellCD3CD4CD127-/+CD95CD25 / TCRCD45 ROMemorycellCD3CD4CD127CD62 LCD25CD45 ROMemorycellCD3 / TCRCD8 CD45 RAEffectorcellCD3 / TCRCD8 CD4+CD8 +(DP)CD4+8+(DP)CD4+8+(DP)CD4+8+(DP)Macro -phageDendriticcellEpithelialcellEpithel ialcellCD4+8+(DP)Thymus seedingprogenitorHuman T cell developmentTo find out more, please visit 2018 Abcam . All rights reserv
