Streptococcus gallolyticus subsp. pasteurianus - jscm.org

1 Streptococcus 1 1) 3) Q1) 1) 1) 1) 1), 2)1) ! "#$ 2) "#$ 3)% &'( * + 23 4-6 . 23 8-24 .# 1212 13 $ 4 %5 Streptococcus 89: & <'=> @ B E G )DI8* StreptococciKL 12 P VITEK2Q 16S rRNA Q , V S. / 2KL P -. Z [0P\1KL Key words: Streptococcus 16S rRNA]^ 3 , _ 5a b1cde %5 7%fN a a Qi a %f 21) j N k Escherichia coli, Streptococcus agalactiae,_ Listeria monocytogenesK:75 8 Nn12ko % >pq 2/10,000r ?r \ 2/1,000r stK @ PBoNn12ko w5 D% :25 K 2 P Nx GK%5 N L 2) Strepococcus 2003 Schlegel Streptococcus bovisbio-type II-2{ HI| 2 KL 3) / a 5 ~ H S. bovisN ka 4) 5)Qi J L P S. HK J 2KL %5 Q w { S. & LM ( 589 8511) 377 2 ! "#$ TEL: 072 366 0221 2193 FAX: 072 366 0206E-mail: 5 89: KJ I.}}

2 $13 4 Q 34c5 \1,876 g, cm, Q 2QN k W kr r X Y KL P X [ KL $9 \1,900 gK NQ $13 ]d _ ` b? 8 cd _ok P 2 { q 8.. 7 i P 2 NQ 5 178 / 40 / G m n P 2 Q Q{ P KL => pK qr st ? ko wqr 2Q{ e =>{ w5 P 12 x$ yz K- NQ b9 i P % @} _ #P 12 w #$K w 1,400/mlN? KL P CRP 5=>P 2 G / " Vol. 21 No. 4 2011. / " 201124270mg/dl, mg/dl 85/ml 17mg/dl," %215 mg/dl& '( )*+, - /01 4 '( ) 7 & 9' ampicillin (ABPC), cefotaxime (CTX) @ A %B g H IJ KL @ ' &4 MN@ Q ; ( RS' T @ 4 UV; W ' @ CRP 2 mg/dl, 4S 3 11,200/ml 0 W ] / 2 13,147/ml W ] 2 ^ ;_(01 9' 15 CTX*` ABPC 28 0` & 29 a bCT 61 ' d MRI eM @ a f f& g @ hi , U l m0 ) n 91 2o& II.)}}}

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4 " % * VITEK2 ,-GP. 12 4 2 7 = >? AB *AST-P596 12 4 2 7 DE .. S.. H >? ABI K !> AB . RS TU Q 16S rRNAXYZ [ ] T ` bc d e!f gh. >? ABI i1 MICroFAST Panel type 3J (SIEMENS) jk l nopqr MIC s i1 t u2. n xyz {| 5 ~ 235 18 y g t Enterococcusspp. { yz {| 35 24 y A: KEAyz { 2 t B: EF xyz E. faecalis { e l Vol. 21 No. 4 S. 1,876 g ! # $% ( * + S. S. bovis! - * 2003 /0 1 6) * 1 2 1 * 5 # ( 1 1 8 ;< => ? @A ;< C F GH DI 5 KEnterococcusspp. L M 1 Enterococcusspp. L OP L # CFIX/S WX1 5 clin-damycin MIC Enterococcusspp. Z L ! !" OP \] _ ' L Z ( * a VITEK2 16S rRNA c !))}}}}}

5 1 Haanpera VITEK2 16S rRNA c a,d -ef1 g ijC 46150T VITEK2 l m o * 1 Streptococcus pasteurianus p q Excellent * 7) d ! 0s k 1k c ijC k 2 7) S. 2003 - * g 1 ! t 5 => ? u5 w a x\ ( * X1 y ;{ -ef1 u5 | = ? 2 1@ X} 1 C 1 Q ABPC, CTX9) E * 5 Beck 9) S. X1I benzylpenicillin (PCG) MIC90 , cef-triaxone (CTRX) MIC90 CW 3 W * 1 ABPC , CTX MIC Q * 1 S. bovis \ PCG CTRX P 1 10) S. OP \ ( M ! 1 penicillin-resistantStreptococcus pneumoniae b-lactamase non-producing ampicillin resistantHaemophilus influenzae ( O* G WX1 Q E 8) 1 meropenem MIC ! 0s | Z * 1 S. bovis = RS S ?

6 #5K 5) # #T * U 5 # VRW CT\] R ?MRI\] ;< 5 P; X d IgG 332mg/ml W ( ] dfa ` \] 1 OP X1 MIC (mg/ml)X1 MIC (mg/ml)Benzylpenicillin 1 1 Tetracycline 4 Cefixime 1 Levofloxacin 2 Cefotaxime 4/76 Cefozopran 4 Cefepime 1 Streptococcus gallolyticus 1 1 Streptococcus gallolyticus 1 1 ' 0s c> Vol. 21 No. 4 !"#$ ' ) *+ -. / 012 56 9 ; ? Haemophilus influenzae$ *+ .B E 11) " $ F GH ? I JKL N !"#$ OP Q6 R6 8) STU O!"#$ YZ/ [\ ]^ _ ` a c STU$ O_ [\ 12) *+ ' O Y f ` hi S. STU$ Kj "klmOn " T /#p Enterococcusspp. qr R t v Dw Streptococcusspp. ylm z{# " STU$ / O Y "klm O / O P K U O QT 1) O$ U P 9: 1601 ) 2006.}

7 U STU STU$ p. 2475 2477,;v v 18 I IKBP 3) Schlegel, L., F. Grimont, E. Ageron, P. Gri-mont,et al. 2003. Reappraisal of the taxonomyof theStreptococcus bovis Streptococcus equinuscomplex and related species: Description ofStreptococcus nov.,S. nov. andS. nov. Int. J. Syst. Evol. Microbiol. 53:631 ) Haldane, E. V., J. H. Haldane, G. Digout, A. West,et al. Med. Assoc. J. 111: 678 ) Grant R. J., T. R. Whitehead, J. E. Orr. bovismeningitis in an infant. Microbiol. 38: 462 ) Onoyama, S., R. Ogata, A. Wada, M. Saito, et Neonatal bacterial meningitis caused byStreptococus Microbiol. 58: 1252 ) Haanpera , M., J. Jalava, P. Huovinan, O. Meur-man, et al. 2007. Identification of alpha-hemolytic streptococci by pyrosequencing the16S rRNA gene and by use of VITEK2. J. 45: 762 )!"#$ OL Q6 R6 N 2007.

8 !"#$ OL Q6 R6 JKL 24: 45 ) Beck, M., R. Frodl, G. Funke. 2008. Comprehen-sive study of strains previously designatedStreptococcus bovisconsecutively isolated fromhuman blood cultures and emended descrip-tion ofStreptococcus gallolyticusandStreptococ-cus Clin. Microbiol. 46:2966 ) Gerber, J. S., M. Glas, F. Frank, S. S. Shah. bovisinfection in young Infect. Dis. J. 25: 1069 ) McIntyre, P. B., C. S. Berkey, S. M. King, et Dexamethasone as adjunctive therapy inbacterial meningitis: A meta-analysis of ran-domized clinical trials since 1988. JAMA 278:925 ) Chaudhuri, A. 2004. Adjunctive dexametha-sone treatment in acute bacterial Neurol. 3: 54 62. I T Vol. 21 No. 4 Case of Neonatal Bacterial Meningitis Due toStreptococcus Toda,1)Kiyofumi Ohkusu,3)Michiko Furugaito,1)Koji Utsunomiya,1)Toshihiro Yamaguchi,1)Shochi Naitoh,1)Toshinori Kamisako1), 2)1)Department of Clinical Laboratory, Kinki University Hospital2)Department of Clinical Laboratory Medicine, Kinki University School of Medicine3)Department of Microbiology, Gifu University Graduate School of MedicineWe report a 13-day-old girl who was diagnosed as neonatal meningitis and bacteraemia caused According to the colony and Lancefield s D antigen, the isolated strain wassimilar to the enterococci.

9 From the result of VITEK2 and 16S rRNA gene sequence, the isolate wasidentified withS. Neonatal meningitis due toS. rarely. However, the identification must be careful of the misidentification of gallolyticus 1 Streptococcus gallolyticus 1 Vol. 21 No. 4