Tox considerations for oligonucleotide therapeutics
•Key considerations in preclinical testing - Pharmacological species restriction – Use of murine surrogate of the same ... Concentration-dependent prolongation of aPTT Single-dose, 4-hour Infusion 0.1 1 10 100 1000 0 1 4 4.25 4.5 5 8 12 16 28 52 76 100 168 340 Hours Post-dose 20K PEG-aptamer (ug oligo/mL) 25 35 45 55 65 75 aPTT (sec)
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Testing, Therapeutic, Considerations, Oligonucleotide, Tpat, Considerations for oligonucleotide therapeutics
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